Experimental Study on Endothelial Repair after Mechanical Endothelial Denudation
نویسندگان
چکیده
منابع مشابه
Inhibition of endothelial cell regrowth. Cessation of aortic endothelial cell replication after balloon catheter denudation.
Aortas of male rabbits (2.0 to 2.5 kg body weight) were denuded of endothelium with a 4F balloon catheter and killed 7, 14, 60, 90, and 180 days later. Aortic endothelial cells regrowth was determined using Evans blue dye and scanning electron microscopy. Early endothelial outgrowth was rapid, but by 14 days the regrowth slowed markedly so that no further increase of endothelial outgrowth was d...
متن کاملExpression of endothelin-1 after endothelial denudation of thoracic aortas in experimental hypercholesterolemic rats.
Although endothelin-1 (ET-1) is involved in balloon-induced neointima formation, the role of ET-1 in balloon-induced neointima formation in hypercholesterolemia is unclear. In addition, it remains to be determined whether ET-1 is produced by endothelial cells or vascular smooth muscle cells, or both. We investigated tissue immunoreactive ET-1 levels by immunoblot analysis, localization of ET-1 ...
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BACKGROUND AND PURPOSE Endovascular treatment can improve the outcome of patients treated for ruptured intracranial aneurysms as compared with surgical clipping, but angiographic recurrences are frequent. Endothelial denudation before coil embolization may prevent recanalization and improve results of endovascular treatment. METHODS We compared angiographic and pathological results 3 months a...
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Vascular endothelial growth factor (VEGF) is highly expressed in vascular remodeling processes and accelerates reendothelialization after mechanical denudation. Two VEGF tyrosine kinase receptors have been reported-fms-like-tyrosine kinase-1 (Flt-1) and kinase domain region (KDR). Little is known about the regulation of the expression of these receptors after vascular injury. Herein, we have an...
متن کاملEndothelial dysfunction and denudation in rat aortic allografts.
Clinical evidence suggests that early endothelial cell (EC) dysfunction may predict the development of graft vascular disease. We wished to assess the early functional and morphological changes in the graft endothelium in a commonly used animal model of graft vascular disease, the rat aortic interposition allograft model. To assess graft EC function, regulation of vascular tone by ECs was monit...
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ژورنال
عنوان ژورنال: The Journal of Japan Atherosclerosis Society
سال: 1994
ISSN: 0386-2682,2185-8284
DOI: 10.5551/jat1973.21.11-12_681